| Schauspieler | Rolle | Synchronsprecher | ||
| Christina Applegate Christina Applegate | Reagan Brinkley | Claudia Lössl Claudia Lössl | ||
| Maya Rudolph | Ava Alexander | Silke Matthias | ||
| Jennifer Hall | Missy | Manja Doering Manja Doering | ||
| Will Arnett Will Arnett | Chris Brinkley | Martin Kautz Martin Kautz | ||
| Matt Braunger | Gene Martin | Stefan Fredrich Stefan Fredrich | ||
| Luka Jones | Scott Chafin | Daniel Zillmann Daniel Zillmann | ||
| Alanis Morissette | Amanda | Claudia Urbschat Mingues Claudia Urbschat Mingues | ||
| Jorma Taccone | Benjamin Roth aka b-ro | Oliver Bender Oliver Bender | ||
| Nick Cannon | Calvin | Tim Sander Tim Sander | ||
| Jenn Korbee | Charlotte | Friederike Walke | ||
| Mary Elizabeth Ellis | Connie | Victoria Sturm Victoria Sturm | ||
| Paul F. Tompkins | Dave | Christian Gaul Christian Gaul | ||
| Blythe Danner Blythe Danner | Dr. Angie Chafin | Karin Buchholz Karin Buchholz | ||
| Richard Schiff | Dr. Dean Chafin | Kaspar Eichel Kaspar Eichel | ||
| Japheth Gordon | Dr. Deon | Valentin Stilu Valentin Stilu | ||
| Sam Page | Dr. Goddard | Roland Wolf Roland Wolf | ||
| Tony Hale | Dr. Welborn | Gerrit Schmidt-Foß Gerrit Schmidt-Foß | ||
| Dioni Michelle Collins | Hilary | Dana Friedrich Dana Friedrich | ||
| Rob Huebel | Jerry | Viktor Neumann Viktor Neumann | ||
| Kate French | Jessie | Dascha Lehmann Dascha Lehmann | ||
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