| Schauspieler | Rolle | Synchronsprecher | ||
| Javier Bardem Javier Bardem | Pablo Escobar | Carlos Lobo Carlos Lobo | ||
| Penélope Cruz Penélope Cruz | Virginia Vallejo | Claudia Lössl Claudia Lössl | ||
| Peter Sarsgaard Peter Sarsgaard | Agent Shepard | Johannes Raspe Johannes Raspe | ||
| Quique Mendoza | Abel Monje | Paul Sedlmeir Paul Sedlmeir | ||
| David Valencia | Agent Santos | Leonard Hohm | ||
| Álvaro García | Alfonso López Michelsen | Claus Brockmeyer | ||
| James Lawrence | Botschafter Williams | Alexander Pelz | ||
| Ricardo Niño | Careta | Matthias Ransberger | ||
| Juan Sebastián Calero | Carlos Corral | Martin Müller | ||
| Luis Fernando Hoyos | Colonel Méndez | Jacques Breuer Jacques Breuer | ||
| Juan Pablo Gamboa | Direktor TV | Walter von Hauff Walter von Hauff | ||
| Julio Nava | Garza | Stefan Lehnen | ||
| Pedro Calvo | Gatillero | Arne Hörmann | ||
| Santiago Londoño | Hermosilla | Pascal Fligg | ||
| Colin Salmon | High State US Official | Marc Rosenberg | ||
| Santiago Soto | Ignacio Castro | Josef Vossenkuhl | ||
| Joavany Alvarez | Ignacio Velarde | Martin Halm | ||
| Carlos Ramirez | Juan Pablo | Moritz Blaich | ||
| Nicolas Gonzales | Juan Pablo (Teenager) | Laurin Lechenmayr | ||
| Oscar Rodriguez | Kampagnen-Manager | Andreas Thiele | ||
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