| Schauspieler | Rolle | Synchronsprecher | ||
| Will Ferrell Will Ferrell | Sherlock Holmes | Uwe Büschken Uwe Büschken | ||
| John C. Reilly John C. Reilly | Dr. John Watson | Detlef Bierstedt Detlef Bierstedt | ||
| Rebecca Hall Rebecca Hall | Grace Hart | Manja Doering Manja Doering | ||
| Rob Brydon | Inspektor Lestrade | Florian Halm Florian Halm | ||
| Kelly Macdonald Kelly Macdonald | Mrs. Martha Hudson | Nicole Hannak Nicole Hannak | ||
| Lauren Lapkus Lauren Lapkus | Millie | Josephine Schmidt Josephine Schmidt | ||
| Ralph Fiennes Ralph Fiennes | Prof. James Moriarty / Jacob Musgrave | Udo Schenk | ||
| Russell Wilcox | Ansager | Edwin Gellner | ||
| Joseph Macnab | Ausbilder | Edwin Gellner | ||
| Darren Lake | desorientierter Typ | Edwin Gellner | ||
| Noah Jupe | Doxy | Matti Pillmann | ||
| Bella Ramsey | Flotsam | Jada Zech | ||
| Steve Coogan Steve Coogan | Gustav Klinger | Oliver Stritzel Oliver Stritzel | ||
| Hugh Laurie Hugh Laurie | Mycroft Holmes | K.Dieter Klebsch K.Dieter Klebsch | ||
| Scarlet Grace | Pickle | Derya Akyol | ||
| Michael Culkin | Richter Over | Jürgen Kluckert Jürgen Kluckert | ||
| David Bromley | telefonierender Typ | Sascha Krüger Sascha Krüger | ||
| Oliver Maltman | Telegraph Operator | Sascha Krüger Sascha Krüger | ||
| David Stoller | Wache | Sven Brieger Sven Brieger | ||
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