| Schauspieler | Rolle | Synchronsprecher | ||
| Tobey Maguire Tobey Maguire | Homer Wells | Florian Bauer | ||
| Charlize Theron Charlize Theron | Candy Kendall | Anna Carlsson | ||
| Paul Rudd Paul Rudd | Wally Worthington | Philipp Brammer Philipp Brammer | ||
| Sir Michael Caine Sir Michael Caine | Dr. Wilbur Larch | Jürgen Thormann Jürgen Thormann | ||
| Kieran Culkin Kieran Culkin | Buster | Dominik Hartinger | ||
| Delroy Lindo | Arthur Rose | Bert Franzke Bert Franzke | ||
| Jane Alexander | Schwester Edna | Elisabeth Endriss | ||
| Erykah Badu | Rose Rose | Sandra Schwittau Sandra Schwittau | ||
| Earle C. Batchelder | Dr. Holtz | Tonio von der Meden | ||
| Evan Parke | Jack | Frank Muth | ||
| Norma Fine | Mrs. Goodhall | Ursula Traun | ||
| K. Todd Freeman | Muddy | Ole Pfennig | ||
| Heavy D | Peaches | Torsten Münchow Torsten Münchow | ||
| Lonnie Farmer | Hero | Thomas "Tommi" Piper Thomas "Tommi" Piper | ||
| Patrick Donnelly | Adoptivvater | Hubertus von Lerchenfeld | ||
| Kevin Chapman Kevin Chapman | Adoptierender Ehemann | Nicht synchronisiert | ||
| Sean Andrew | Copperfield | Benjamin Levent Krause | ||
| Spencer Diamond | Curly | Christoph Dirscherl | ||
| Erik Per Sullivan | Fuzzy | Maximilian Kuber | ||
| Kathy Baker | Krankenschwester Angela | Jutta Speidel | ||
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